A Guide to Treatment-Resistant Depression

When Traditional Treatments Don’t Work: A Guide to Treatment-Resistant Depression (TRD)


Depression affects millions of people every year — but for some, traditional treatments like antidepressants and talk therapy just don’t work. If you or someone you love has tried multiple medications or therapies and still struggles with symptoms, you may be dealing with Treatment-Resistant Depression (TRD).


At Blue Umbrella Psychiatry, we understand how discouraging this can feel — and we want you to know you’re not out of options.


What Is Treatment-Resistant Depression?


Treatment-resistant depression is typically diagnosed when a person has not responded to at least two different antidepressant trials, each given at an appropriate dose and duration. This kind of depression is more common than many realize — and it doesn’t mean you’ve failed treatment. It simply means your brain may need a different approach.


Why Standard Treatments Sometimes Fall Short


Depression is complex. It can be influenced by brain chemistry, trauma, chronic stress, genetics, or even underlying medical conditions. In some cases, medication alone isn’t enough. For others, the side effects of traditional antidepressants may be too difficult to tolerate. This is where advanced options come in.


New Hope with Breakthrough Treatments


At Blue Umbrella Psychiatry, we offer cutting-edge solutions for TRD, including:

  • TMS (Transcranial Magnetic Stimulation): A non-invasive, FDA-approved treatment that uses magnetic pulses to stimulate brain regions involved in mood regulation.
  • Spravato (esketamine): A nasal spray approved for TRD, working on glutamate pathways to relieve symptoms more quickly than traditional meds.
  • Ketamine Therapy: Administered under medical supervision, ketamine has shown fast-acting relief for many individuals with severe or long-standing depression.
  • Collaborative Care: We also integrate therapy, lifestyle support, and psychiatric medication management to give every patient a personalized, layered plan.


You're Not Alone — and You're Not Stuck


One of the most painful parts of TRD is feeling like nothing will work. But new, science-backed treatments are changing that reality for many people — including our patients.


At Blue Umbrella Psychiatry, we've recently expanded into a new, larger space in Davie to better serve our community. Our dedicated group rooms and private treatment areas allow us to offer more personalized care in a calm, healing environment.



Let’s Talk — We’re Here to Help


If you or a loved one feels stuck, exhausted, or disheartened by past treatments, it’s time for a new approach.


We invite you to explore options like TMS, Ketamine, and Spravato with our experienced team.


At Blue Umbrella Psychiatry, we specialize in helping adults and adolescents facing treatment-resistant depression through compassionate, comprehensive care.


We believe there’s no "one-size-fits-all" approach to healing — and we’re here to create a plan that meets you where you are.


You deserve relief, and there is hope.


Let’s talk.


📍 Now located at 6100 Griffin Rd., 2nd Floor, Davie, FL 33314



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